Affable host Andy Cohen usually gets some good stuff out of his guests, and Tuesday's (March 5) "Watch What Happens Live" with Chelsea Handler was no exception.

First up was the topic of Taylor Swift's offense to a joke told at the Golden Globes by co-hosts Tina Fey and Amy Poehler. After refusing to take sides in the matter, the host of "Chelsea Lately" explained, "My theory about Taylor Swift is that she's a virgin. That everyone breaks up with her after two weeks because she's like 'I'm not gonna do it.' Every guy thinks they're gonna de-virginize her and they're not. She's never gonna get de-virginized. Ever."

Next up, the brazen blonde took on Angelina Jolie, saying, "She seems like a demon. It has nothing to do with Jennifer [Aniston]. As a woman, I know when you see somebody walking across the room, that's a bad girl. I just don't like Angelina Jolie. I just think she's not a girl's girl. I like girl's girls."

The 38-year-old comedian is well-known as a pal of Jennifer Aniston, but repeatedly insisted that her dislike of the actress has nothing to do with her friendship with the "Friends" star. Check out a no-holds barred Ms. Handler in the video below.